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Modelling post-chemotherapy stem cell dynamics in the bone marrow niche of AML patients

Abstract Acute myeloid leukemia (AML) is a stem cell-driven malignancy of the blood forming (hematopoietic) system. Despite of high dose chemotherapy with toxic side effects, many patients eventually relapse. The “7+3 regimen”, which consists of 7 days of cytarabine in combination with daunorubicin...

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Principais autores: Chenxu Zhu, Thomas Stiehl
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-10-01
Serier:Scientific Reports
Fag:
Acute myeloid leukemia (AML)
7+3 chemotherapy
Stem cell niche
Cancer stem cell
Computational model
Mathematical model
Online adgang:https://doi.org/10.1038/s41598-024-75429-7
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