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Short‐term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone‐induced polycystic ovary syndrome mice

Abstract Background Polycystic ovary syndrome (PCOS) is a multifactorial endocrinopathy that affects reproduction and metabolism. Mammalian target of rapamycin (mTOR) has been shown to participate in female reproduction under physiological and pathological conditions. This study aimed to investigate...

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Principais autores: Zaixin Guo, Xiaohan Chen, Penghui Feng, Qi Yu
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-05-01
Serier:Journal of Ovarian Research
Fag:
Polycystic ovary syndrome
mTOR
Rapamycin
Steroidogenesis
Hyperandrogenism
Online adgang:https://doi.org/10.1186/s13048-021-00813-0
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