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Microglial Cells: The Main HIV-1 Reservoir in the Brain

Despite efficient combination of the antiretroviral therapy (cART), which significantly decreased mortality and morbidity of HIV-1 infection, a definitive HIV cure has not been achieved. Hidden HIV-1 in cellular and anatomic reservoirs is the major hurdle toward a functional cure. Microglial cells,...

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Principais autores: Clementine Wallet, Marco De Rovere, Jeanne Van Assche, Fadoua Daouad, Stéphane De Wit, Virginie Gautier, Patrick W. G. Mallon, Alessandro Marcello, Carine Van Lint, Olivier Rohr, Christian Schwartz
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019-10-01
Serier:Frontiers in Cellular and Infection Microbiology
Fag:
HIV-1
Ctip2
microglial cells
reservoirs
latency
brain
Online adgang:https://www.frontiersin.org/article/10.3389/fcimb.2019.00362/full
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