Integrative multiomics analysis reveals the subtypes and key mechanisms of platinum resistance in gastric cancer: identification of KLF9 as a promising therapeutic target

Abstract Background Gastric cancer (GC) is characterized by significant intertumoral heterogeneity, which often leads to the development of resistance to platinum-based chemotherapy. Combining platinum drugs with other therapeutic strategies may improve treatment efficacy; however, the mechanisms un...

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Autores principales:	Pengcheng Zhang, Lexin Wang, Haonan Lin, Yihui Han, Jingfang Zhou, Hang Song, Peng Wang, Huanhuan Tan, Yajuan Fu
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	BMC 2025-08-01
Colección:	Journal of Translational Medicine
Materias:	Gastric cancer Platinum resistance Similarity network fusion Spatial transcriptomics KLF9
Acceso en línea:	https://doi.org/10.1186/s12967-025-06725-7
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