ROCK1 activation-mediated mitochondrial translocation of Drp1 and cofilin are required for arnidiol-induced mitochondrial fission and apoptosis

Abstract Background Arnidiol is a pentacyclic triterpene diol that has multiple pharmacological activities. However, the apoptotic activities of arnidiol in human cancer cells have not yet been explored, nor has the mechanism by which arnidiol induces apoptosis been examined in depth. Methods MDA-MB...

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Hlavní autoři:	Jinjiao Hu, Hongwei Zhang, Jie Li, Xiuxing Jiang, Yanhao Zhang, Qin Wu, liwen Shen, Jingshan Shi, Ning Gao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2020-02-01
Edice:	Journal of Experimental & Clinical Cancer Research
Témata:	ROCK1 Cofilin Drp1 Arnidiol Mitochondrial fission Apoptosis
On-line přístup:	http://link.springer.com/article/10.1186/s13046-020-01545-7
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