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IL-13 as Target to Reduce Cholestasis and Dysbiosis in <i>Abcb4</i> Knockout Mice

The Th2 cytokine IL-13 is involved in biliary epithelial injury and liver fibrosis in patients as well as in animal models. The aim of this study was to investigate IL-13 as a therapeutic target during short term and chronic intrahepatic cholestasis in an <i>Abcb4-</i>knockout mouse model (<i>Abcb4<...

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Principais autores: Luisa Hahn, Nora Helmrich, Diran Herebian, Ertan Mayatepek, Uta Drebber, Eugen Domann, Stefan Olejniczak, Markus Weigel, Torsten Hain, Timo Rath, Stefan Wirtz, Hans-Joachim Mollenkopf, Nadine Schmidt, Christa Ewers, Anne Baier, Yuri Churin, Anita Windhorst, Ralf Weiskirchen, Ulrich Steinhoff, Elke Roeb, Martin Roderfeld
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-08-01
Serier:Cells
Fag:
bile acid
tight junction
Th2
liver fibrosis
bacterial translocation
intestinal microbiome
Online adgang:https://www.mdpi.com/2073-4409/9/9/1949
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