Commonalities in gene expression and methylation changes across two rat models of acquired epilepsy

Abstract Changes in DNA methylation and gene expression play a major role in the epileptogenic process that turns a healthy brain into an epileptic brain. Previous investigations have focused either on changes in the transcriptome or epigenome, but rarely on both. The goal of this combined transcrip...

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Auteurs principaux:	Benton S. Purnell, Junguk Hur, David Ruskin, Madhuvika M. Murugan, Fabio Tescarollo, Riddhimaa Sinha, Nikhil Ramavenkat, Susan A. Masino, Jonathan D. Geiger, Detlev Boison
Format:	Artigo
Langue:	Inglês
Publié:	Nature Portfolio 2026-01-01
Collection:	Scientific Reports
Sujets:	Epilepsy Epileptogenesis Epigenetics DNA methylation Gene expression
Accès en ligne:	https://doi.org/10.1038/s41598-026-35826-6
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