The co-inhibitory receptor TIGIT regulates NK cell function and is upregulated in human intrahepatic CD56bright NK cells

The crosstalk between NK cells and their surrounding environment is enabled through activating and inhibitory receptors, which tightly control NK cell activity. The co-inhibitory receptor TIGIT decreases NK cell cytotoxicity and is involved in NK cell exhaustion, but has also been associated with li...

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Autors principals:	Annerose E. Ziegler, Pia Fittje, Luisa M. Müller, Annika E. Ahrenstorf, Kerri Hagemann, Sven H. Hagen, Leonard U. Hess, Annika Niehrs, Tobias Poch, Gevitha Ravichandran, Sebastian M. Löbl, Benedetta Padoan, Sébastien Brias, Jana Hennesen, Myrtille Richard, Laura Richert, Sven Peine, Karl J. Oldhafer, Lutz Fischer, Christoph Schramm, Glòria Martrus, Madeleine J. Bunders, Marcus Altfeld, Sebastian Lunemann
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2023-02-01
Col·lecció:	Frontiers in Immunology
Matèries:	intrahepatic NK cells liver organoids single-cell mRNA analysis immune tolerance tissue homeostasis TIGIT
Accés en línia:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1117320/full
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