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Drug release from PLGA microparticles can be slowed down by a surrounding hydrogel

This study aimed to evaluate and better understand the potential impact that a layer of surrounding hydrogel (mimicking living tissue) can have on the drug release from PLGA microparticles. Ibuprofen-loaded microparticles were prepared with an emulsion solvent extraction/evaporation method. The drug...

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Main Authors: L.A. Lefol, P. Bawuah, J.A. Zeitler, J. Verin, F. Danede, J.F. Willart, F. Siepmann, J. Siepmann
Format: Artigo
Language:Inglês
Published: Elsevier 2023-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
PLGA
Microparticles
Drug release mechanism
Experimental setup
Swelling
Agarose gel
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156723000646
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