Enantioselective Reductive Alkenylation of α‐CF2H (‐CF3) Amino Halides: Rapid Access to Chiral α‐CF2H (‐CF3) Allylamines

ABSTRACT The incorporation of fluoroalkyl groups into drug candidates has garnered increasing attention in the pharmaceutical industry due to their ability to modulate lipophilicity, permeability, metabolic stability, and binding affinity. Despite significant advances realized, the means to introduc...

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Auteurs principaux:	Peng Liu, Kuiliang Li, Yan He, Chen‐Hui Jiang, Ruo‐Xing Jin, Duo‐Duo Hu, Wei‐Cheng Zhao, Xuan Nie, Shang‐Zheng Sun, Xi‐Sheng Wang
Format:	Artigo
Langue:	Inglês
Publié:	Wiley 2026-03-01
Collection:	Advanced Science
Sujets:	α‐CF2H amines CF2H synthons enantioselective nickel catalysis reductive coupling
Accès en ligne:	https://doi.org/10.1002/advs.73986
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