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Thrombopoietin mimetic therapy alleviates radiation-induced bone marrow vascular injury in a bone marrow transplant mouse model

BackgroundThere is a need for therapies that can mitigate bone marrow dysfunction and organ toxicity that occur following myeloablative injury and reduced intensity conditioning regimens used in patients undergoing bone marrow transplantation (BMT). The pathogenesis of adverse effects from BMT condi...

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Principais autores: Hemendra Ghimire, Srideshikan Sargur Madabushi, Justin Vercellino, Jamison Brooks, Darren Zuro, Ji Eun Lim, Paresh Vishwasrao, Amr Mohamed Hamed Abdelhamid, Guy Strome, Gary Eichenbaum, Monzr Al Malki, Chandan Guha, Susanta K. Hui
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-10-01
Serier:Frontiers in Oncology
Fag:
bone marrow transplantation
confocal microscopy
intravital multiphoton microscopy
thrombopoietin mimetic
x-ray irradiation
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1414488/full
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