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Endolysosomal dysfunction impairs proteostasis and induces neurodegeneration in vivo

Summary: Transactive response (TAR) DNA-binding protein 43 (TDP-43) inclusions are a pathological hallmark of the frontotemporal dementia (FTD)-amyotrophic lateral sclerosis (ALS) spectrum. Dysfunction of the endolysosomal system, which plays a crucial role in protein trafficking and maintaining pro...

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Hoofdauteurs: Wei Shao, Ellen A. Albagli, Karen Jansen-West, Lillian M. Daughrity, Jimei Tong, Anxhela Hysi, Peizhou Jiang, Tiffany W. Todd, Emma Lee, Desiree Zanetti Alepuz, Yari Carlomagno, Mei Yue, Judith A. Dunmore, Monica Castanedes-Casey, Paula Castellanos Otero, Aishe Kurti, Mercedes Prudencio, Casey N. Cook, Dennis W. Dickson, Tania F. Gendron, Leonard Petrucelli, Yong-Jie Zhang
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2025-10-01
Reeks:iScience
Onderwerpen:
developmental neuroscience
molecular neuroscience
technical aspects of cell biology
Online toegang:http://www.sciencedirect.com/science/article/pii/S2589004225017213
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