Differential regulatory mechanisms of gut-derived SCFAs (acetate, propionate, butyrate) on the pulmonary TLR2 signaling pathway and their roles in the inflammatory balance of bacterial pneumonia

Abstract Gut microbiota-derived short-chain fatty acids (SCFAs), key mediators in gut–lung axis interactions, profoundly influence pulmonary immune homeostasis. Toll-like receptor 2 (TLR2) is crucial for initiating innate immunity against bacterial pneumonia by recognizing bacterial molecular patter...

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Príomhchruthaitheoirí:	Hang Chen, Yan Xu, Jianli Qiu, Zhiwei Guan, Suping Yu, Ying Ding
Formáid:	Artigo
Teanga:	Inglês
Foilsithe / Cruthaithe:	BMC 2026-01-01
Sraith:	European Journal of Medical Research
Ábhair:	Gut-derived short-chain fatty acids (SCFAs) Pulmonary Toll-like receptor 2 (TLR2) signaling pathway Bacterial pneumonia Gut–lung axis G protein-coupled receptors (GPRs) Histone deacetylase (HDAC) inhibition
Rochtain ar líne:	https://doi.org/10.1186/s40001-025-03666-1
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