Tamoxifen Derivatives Alter Retromer-Dependent Endosomal Tubulation and Sorting to Block Retrograde Trafficking of Shiga Toxins

Shiga toxin 1 and 2 (STx1 and STx2) undergo retrograde trafficking to reach the cytosol of cells where they target ribosomes. As retrograde trafficking is essential for disease, inhibiting STx1/STx2 trafficking is therapeutically promising. Recently, we discovered that the chemotherapeutic drug tamo...

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Bibliografische Detailangaben

Hauptverfasser:	Andrey S. Selyunin, Karinel Nieves-Merced, Danyang Li, Stanton F. McHardy, Somshuvra Mukhopadhyay
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2021-06-01
Schriftenreihe:	Toxins
Schlagworte:	Shiga toxin Shiga toxin 2 tamoxifen retromer trafficking Golgi
Online-Zugang:	https://www.mdpi.com/2072-6651/13/6/424
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