Experimental evidence that readily diffusible forms of Aβ from Alzheimer’s disease brain have seeding activity

Abstract Significant data suggest that cerebral accumulation of the amyloid β-protein (Aβ) plays an initiating role in Alzheimer’s disease (AD), however, Aβ can exist in multiple different forms and it is not clear which of these contribute to the propagation of amyloid or toxicity. When injected in...

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Principais autores:	Simin Song, Qianmin Liu, Ruixiang Chen, Ping Chen, Min Tao, Siyao Li, Liping Guo, Xixi Zhu, Yan Liu, Lu Liu, Hiroki Sasaguri, Takashi Saito, Takaomi C. Saido, Dominic M. Walsh, Zhangjin Zhang, Wei Hong
格式:	Artigo
語言:	Inglês
出版:	BMC 2025-05-01
叢編:	Acta Neuropathologica Communications
主題:	Amyloid β-protein Cognitive impairment Gliosis Neuronal loss Neurotoxicity Prion-like spreading
在線閱讀:	https://doi.org/10.1186/s40478-025-02032-w
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