Involvement of naïve T cells in the pathogenesis of osimertinib-induced pneumonitis

Abstract Osimertinib, a third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, effectively treats EGFR-mutated non-small cell lung cancer. Drug-induced interstitial lung disease, a potentially fatal complication of osimertinib, involves an increase in lymphocytes in the...

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Autores principales:	Hiroyuki Ando, Kazuya Tsubouchi, Toyoshi Yanagihara, Kentaro Hata, Daisuke Eto, Kunihiro Suzuki, Naoki Hamada, Isamu Okamoto
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-03-01
Colección:	Scientific Reports
Materias:	Osimertinib Pneumonitis Naïve T cells Epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) CCL21
Acceso en línea:	https://doi.org/10.1038/s41598-025-95271-9
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