Roscovitine derivative optimization via molecular dynamics reveals potent and selective CDK5 binders
CDK5 is an atypical member of the CDKs family that is not directly involved in cell cycle regulation but has a very relevant role in promoting DNA damage response and immune response evasion in cancer. Its action in these tasks conflicts with those of other CDKs, namely CDK4 and CDK6. It is therefor...
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| Principais autores: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Frontiers Media S.A.
2026-02-01
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| coleção: | Frontiers in Chemical Biology |
| Assuntos: | |
| Acesso em linha: | https://www.frontiersin.org/articles/10.3389/fchbi.2026.1741100/full |
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