Chromatin accessibility mapping identifies mediators of basal transcription and retinoid-induced repression of OTX2 in medulloblastoma.

Despite an emerging understanding of the genetic alterations giving rise to various tumors, the mechanisms whereby most oncogenes are overexpressed remain unclear. Here we have utilized an integrated approach of genomewide regulatory element mapping via DNase-seq followed by conventional reporter as...

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Bibliografische gegevens

Hoofdauteurs:	Matthew Wortham, Changcun Guo, Monica Zhang, Lingyun Song, Bum-Kyu Lee, Vishwanath R Iyer, Terrence S Furey, Gregory E Crawford, Hai Yan, Yiping He
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Public Library of Science (PLoS) 2014-01-01
Reeks:	PLoS ONE
Online toegang:	http://europepmc.org/articles/PMC4157845?pdf=render
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