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Skeletal muscle mitochondrial inertia is associated with carnitine acetyltransferase activity and physical function in humans

BACKGROUND At the onset of exercise, the speed at which phosphocreatine (PCr) decreases toward a new steady state (PCr on-kinetics) reflects the readiness to activate mitochondrial ATP synthesis, which is secondary to Acetyl-CoA availability in skeletal muscle. We hypothesized that PCr on-kinetics a...

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Principais autores: Rodrigo F. Mancilla, Lucas Lindeboom, Lotte Grevendonk, Joris Hoeks, Tim R. Koves, Deborah M. Muoio, Patrick Schrauwen, Vera Schrauwen-Hinderling, Matthijs K.C. Hesselink
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2023-01-01
Serier:JCI Insight
Fag:
Aging
Metabolism
Online adgang:https://doi.org/10.1172/jci.insight.163855
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