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Spontaneous Development of Dental Dysplasia in Aged <i>Parp-1</i> Knockout Mice

Poly(ADP-ribose) polymerase (Parp)-1 catalyzes polyADP-ribosylation using NAD<sup>+</sup> and is involved in the DNA damage response, genome stability, and transcription. In this study, we demonstrated that aged <i>Parp-1<sup>&#8722;/&#8722;</sup></i> mouse incisors showed more frequent dental dyspl...

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Autori principali: Hisako Fujihara, Tadashige Nozaki, Masahiro Tsutsumi, Mayu Isumi, Shinji Shimoda, Yoshiki Hamada, Mitsuko Masutani
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2019-09-01
Serie:Cells
Soggetti:
poly(adp-ribose) polymerase-1
aged mice
knockout mice
dental dysplasia
Accesso online:https://www.mdpi.com/2073-4409/8/10/1157
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