CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of β-catenin/LEF1 complex via effects on chromatin remodeling

Abstract Background CircMYO10 is a circular RNA generated by back-splicing of gene MYO10 and is upregulated in osteosarcoma cell lines, but its functional role in osteosarcoma is still unknown. This study aimed to clarify the mechanism of circMYO10 in osteosarcoma. Methods CircMYO10 expression in 10...

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Hlavní autoři:	Junxin Chen, Gang Liu, Yizheng Wu, Jianjun Ma, Hongfei Wu, Ziang Xie, Shuai Chen, Yute Yang, Shengyu Wang, Panyang Shen, Yifan Fang, Shunwu Fan, Shuying Shen, Xiangqian Fang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2019-10-01
Edice:	Molecular Cancer
Témata:	Osteosarcoma Circular RNA circMYO10 RUVBL1 Wnt/β-catenin signaling EMT
On-line přístup:	http://link.springer.com/article/10.1186/s12943-019-1076-1
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