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Altered pathways and targeted therapy in double hit lymphoma

Abstract High-grade B-cell lymphoma with translocations involving MYC and BCL2 or BCL6, usually referred to as double hit lymphoma (DHL), is an aggressive hematological malignance with distinct genetic features and poor clinical prognosis. Current standard chemoimmunotherapy fails to confer satisfyi...

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Principais autores: Yuxin Zhuang, Jinxin Che, Meijuan Wu, Yu Guo, Yongjin Xu, Xiaowu Dong, Haiyan Yang
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-03-01
coleção:Journal of Hematology & Oncology
Assuntos:
Double hit lymphoma
Diffuse large B-cell lymphoma
Genetic alterations
Targeted therapy
Chemotherapy
Acesso em linha:https://doi.org/10.1186/s13045-022-01249-9
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