Recombinant ACE2 Expression Is Required for SARS-CoV-2 To Infect Primary Human Endothelial Cells and Induce Inflammatory and Procoagulative Responses

ABSTRACT SARS-CoV-2 causes COVID-19, an acute respiratory distress syndrome (ARDS) characterized by pulmonary edema, viral pneumonia, multiorgan dysfunction, coagulopathy, and inflammation. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) receptors to infect and damage ciliated epithelial cell...

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Bibliografische Detailangaben

Hauptverfasser:	Jonas Nascimento Conde, William R. Schutt, Elena E. Gorbunova, Erich R. Mackow
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology 2020-12-01
Schriftenreihe:	mBio
Schlagworte:	ACE2 COVID-19 SARS-CoV-2 coagulopathy endothelial cells endotheliitis
Online-Zugang:	https://journals.asm.org/doi/10.1128/mBio.03185-20
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