Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes

Abstract Ubiquitination is the key eukaryotic post-translational modification that governs protein degradation, localisation, and activity which is mediated by a concerted enzyme cascade. The largest superfamily of these enzymes include the Cullin-RING-Ligase (CRL) complexes. Plasmodium falciparum,...

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Autores principales:	Danushka Marapana, Simon A. Cobbold, Michal Pasternak, Gerald J. Shami, Stuart A. Ralph, Sash Lopaticki, Jumana Yousef, Vineet Vaibhav, Laura F. Dagley, David Komander, Alan F. Cowman
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Nature Portfolio 2025-07-01
Colección:	Scientific Reports
Materias:	Malaria E3 ligase Cullin-ring-ligase P. falciparum Ubiquitination
Acceso en línea:	https://doi.org/10.1038/s41598-025-05342-0
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