A novel class of apical sodium--dependent bile salt transporter inhibitors: 1-(2,4-bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides

The apical sodium--dependent bile acid transporter (ASBT) is the main transporter to promote re-absorption of bile acids from the intestinal tract into the enterohepatic circulation. Inhibition of ASBT could increase the excretion of bile acids, thus increasing bile acid synthesis and consequently c...

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Autores principales:	Hongtao Liu, Guoxun Pang, Jinfeng Ren, Yue Zhao, Juxian Wang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2017-03-01
Colección:	Acta Pharmaceutica Sinica B
Materias:	ASBT inhibitors Bile acids 1-(2,4-Bifluorophenyl)-7-dialkylamino-1,8-naphthyridine-3-carboxamides Cholesterol-lowering drug NC-1
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2211383516302040
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