Identifying new biomarkers of aggressive Group 3 and SHH medulloblastoma using 3D hydrogel models, single cell RNA sequencing and 3D OrbiSIMS imaging

Abstract The most common malignant brain tumour in children, medulloblastoma (MB), is subdivided into four clinically relevant molecular subgroups, although targeted therapy options informed by understanding of different cellular features are lacking. Here, by comparing the most aggressive subgroup...

Descripció completa

Dades bibliogràfiques

Autors principals:	Franziska Linke, James E. C. Johnson, Stefanie Kern, Christopher D. Bennett, Anbarasu Lourdusamy, Daniel Lea, Steven C. Clifford, Catherine L. R. Merry, Snow Stolnik, Morgan R. Alexander, Andrew C. Peet, David J. Scurr, Rian L. Griffiths, Anna M. Grabowska, Ian D. Kerr, Beth Coyle
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2023-01-01
Col·lecció:	Acta Neuropathologica Communications
Matèries:	Medulloblastoma Group 3 SHH Tricarboxylic acid (TCA) cycle Small leucine-rich proteoglycans (SLRPs)
Accés en línia:	https://doi.org/10.1186/s40478-022-01496-4
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!