Advanced patient-specific microglia cell models for pre-clinical studies in Alzheimer’s disease

Abstract Background Alzheimer’s disease (AD) is an incurable neurodegenerative disorder with a rapidly increasing prevalence worldwide. Current approaches targeting hallmark pathological features of AD have had no consistent clinical benefit. Neuroinflammation is a major contributor to neurodegenera...

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Hlavní autoři:	Carla Cuní-López, Romal Stewart, Lotta E. Oikari, Tam Hong Nguyen, Tara L. Roberts, Yifan Sun, Christine C. Guo, Michelle K. Lupton, Anthony R. White, Hazel Quek
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2024-02-01
Edice:	Journal of Neuroinflammation
Témata:	Microglia Monocytes Patient Alzheimer’s disease 3D cell modeling Drugs
On-line přístup:	https://doi.org/10.1186/s12974-024-03037-3
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