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Chalcone-Derived Nrf2 Activator Protects Cognitive Function via Maintaining Neuronal Redox Status

NF-E2-related factor 2 (Nrf2), the key transcription regulator of phase II enzymes, has been considered beneficial for neuronal protection. We previously designed a novel chalcone analog, 1-(2,3,4-trimethoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-acrylketone (Tak), that could specifically activate Nrf2 i...

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Autori principali: Yuting Cui, Yue Xiong, Hua Li, Mengqi Zeng, Yan Wang, Yuan Li, Xuan Zou, Weiqiang Lv, Jing Gao, Ruijun Cao, Lingjie Meng, Jiangang Long, Jiankang Liu, Zhihui Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-11-01
Serie:Antioxidants
Soggetti:
phase II enzymes
Nrf2
Akt
hippocampus
mitochondrial function
Accesso online:https://www.mdpi.com/2076-3921/10/11/1811
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