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Optimization of the MACE endpoint composition to increase power in studies of lipid-lowering therapies—a model-based meta-analysis

AimsTo develop a model-informed methodology for the optimization of the Major Adverse Cardiac Events (MACE) composite endpoint, based on a model-based meta-analysis across anti-hypercholesterolemia trials of statin and anti-PCSK9 drugs.Methods and resultsMixed-effects meta-regression modeling of sta...

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Principais autores: Alina Volkova, Boris Shulgin, Gabriel Helmlinger, Kirill Peskov, Victor Sokolov
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-01-01
coleção:Frontiers in Cardiovascular Medicine
Assuntos:
MACE
cardiovascular disease
dyslipidemia biomarkers
lipid-lowering medication
model-based meta-analysis
sample size
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1242845/full
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