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Fyn Phosphorylates Transglutaminase 2 (Tgm2) and Modulates Autophagy and p53 Expression in the Development of Diabetic Kidney Disease

Autophagy is involved in the development of diabetic kidney disease (DKD), the leading cause of end-stage renal disease. The Fyn tyrosine kinase (Fyn) suppresses autophagy in the muscle. However, its role in kidney autophagic processes is unclear. Here, we examined the role of Fyn kinase in autophag...

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Principais autores: Ryota Uehara, Eijiro Yamada, Shuichi Okada, Claire C. Bastie, Akito Maeshima, Hidekazu Ikeuchi, Kazuhiko Horiguchi, Masanobu Yamada
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2023-04-01
coleção:Cells
Assuntos:
autophagy
diabetic
end-stage renal disease
hyperglycemia
kidney
Acesso em linha:https://www.mdpi.com/2073-4409/12/8/1197
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