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Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects

Deficiency of the small Maf proteins Mafg and Mafk cause multiple defects, namely, progressive neuronal degeneration, cataract, thrombocytopenia and mid-gestational/perinatal lethality. Previous data shows Mafg−/−:Mafk+/- compound knockout (KO) mice exhibit cataracts age 4-months onward. Strikingly,...

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Egile Nagusiak: Shaili D. Patel, Deepti Anand, Hozumi Motohashi, Fumiki Katsuoka, Masayuki Yamamoto, Salil A. Lachke
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2022-08-01
Saila:Frontiers in Cell and Developmental Biology
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Sarrera elektronikoa:https://www.frontiersin.org/articles/10.3389/fcell.2022.981893/full
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