Decreased hepatic accumulation and enhanced esterification of cholesterol in mice deficient in mdr1a and mdr1b P-glycoproteins

Class I P-glycoproteins [Pgp; MDR1 (ABCB1) in humans, mdr1a and mdr1b in mice] confer resistance to structurally diverse chemotherapeutic drugs in cultured cells and intact animals, but the function of these proteins in normal physiology remains poorly characterized. Based on studies in cell culture...

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Detalhes bibliográficos

Principais autores:	Gary D. Luker, Julie L. Dahlheimer, Richard E. Ostlund, Jr., David Piwnica-Worms
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2001-09-01
coleção:	Journal of Lipid Research
Assuntos:	ATP-binding cassette transporters multidrug resistance liver transgenic animals
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520302704
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