A mini review of genome-predicted β-lactam susceptibility in Streptococcus pneumoniae: from PBP profiles to potential clinical interpretation

β-Lactams remain central to the treatment of pneumococcal infections, and whole-genome sequencing increasingly enables pneumococcal β-lactam susceptibility to be inferred from the combined transpeptidase-domain sequences of PBP1a, PBP2b, and PBP2x. PBP-profile lookup, statistical models, and integra...

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Principais autores:	Ziyi Yan, Li Liu, Yanying Ren, Jiaji Ling, Jing Liao, Xingxin Liu, Yingying Li, Xia Wang, Linghan Kuang, Wei Zhou, Yongmei Jiang, Yali Cui
Format:	Artigo
Jezik:	Inglês
Izdano:	Frontiers Media S.A. 2026-07-01
Serija:	Frontiers in Cellular and Infection Microbiology
Teme:	antimicrobial susceptibility minimum inhibitory concentration penicillin-binding proteins Streptococcus pneumoniae whole-genome sequencing β-lactam susceptibility
Online dostop:	https://www.frontiersin.org/articles/10.3389/fcimb.2026.1901030/full
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