Mitogen-activated protein kinase kinase 4 (MKK4) as a promising therapeutic target in liver diseases: a review

The liver is essential for metabolism and detoxification and can regenerate effectively. However, severe injuries or major surgeries can hinder this ability, leading to liver insufficiency or failure. Recent research has identified mitogen-activated protein kinase kinase 4 (MKK4) as a key negative r...

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Detalhes bibliográficos

Principais autores:	Pan Liu, Yangyang Liu, Li Cheng, Tingting Bao, Jingjing Li, Junlong Wu, Jicheng Han, Ting Li, Dongna Zhang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
coleção:	Journal of Enzyme Inhibition and Medicinal Chemistry
Assuntos:	Liver regeneration MKK4 small-molecule inhibitor drug discovery target therapies
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/14756366.2026.2612805
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