HuD impairs neuromuscular junctions and induces apoptosis in human iPSC and Drosophila ALS models
Abstract Defects at the neuromuscular junction (NMJ) are among the earliest hallmarks of amyotrophic lateral sclerosis (ALS). According to the “dying-back” hypothesis, NMJ disruption not only precedes but also triggers the subsequent degeneration of motoneurons in both sporadic (sALS) and familial (...
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| Autori principali: | , , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Portfolio
2024-11-01
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| Serie: | Nature Communications |
| Accesso online: | https://doi.org/10.1038/s41467-024-54004-8 |
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