Lipidation of a nuclear localization sequence enhances broad-spectrum antimicrobial activity: synthesis, characterization, and in silico analysis

Lipidation enhances the antimicrobial potential of cationic peptides by increasing amphiphilicity. The nuclear localization signal peptide PKKKRKV, although cell-penetrating, has weak intrinsic antimicrobial activity. This study evaluates whether conjugation with fatty acids of varying chain lengths...

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Hlavní autoři:	Rani Maharani, Taufik Muhammad Fakih, Muhamad Imam Muhajir, Anggun Fuji Rizqiyani, Ace Tatang Hidayat, Reza Aditama, Retno Lestari, Doddy Irawan Setyo Utomo, Tarwadi Tarwadi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Taylor & Francis Group 2026-12-01
Edice:	Artificial Cells, Nanomedicine, and Biotechnology
Témata:	Lipopeptide PKKKRKV peptide solid-phase peptide synthesis antimicrobial lipopeptide computational design lipidation
On-line přístup:	https://www.tandfonline.com/doi/10.1080/21691401.2026.2649071
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