Cytosine arabinoside-metabolizing enzyme genes are underexpressed in children with MLL gene-rearranged acute lymphoblastic leukemia

Infant acute lymphoblastic leukemia (IALL) is characterized by mixed lineage leukemia (MLL) gene rearrangements, unique gene expression profiles, poor prognosis, and drug resistance. One exception is cytosine arabinoside (Ara-C) to which IALL cells seem to be more sensitive. We quantified mRNA expre...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	J.F. Mata, C.A. Scrideli, R.P. Queiroz, B.O. Mori, M. Emerenciano, M.S. Pombo-de-Oliveira, L.G. Tone
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Associação Brasileira de Divulgação Científica 2006-11-01
סדרה:	Brazilian Journal of Medical and Biological Research
נושאים:	Cytosine arabinoside Acute lymphoblastic leukemia Infant Mixed lineage leukemia gene rearrangement Gene expression
גישה מקוונת:	http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2006001100005
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