Determining the affinities of high-affinity antibodies using KinExA and surface plasmon resonance

Accurate and efficient affinity measurement techniques are essential for the biophysical characterization of therapeutic monoclonal antibodies, one of the fastest growing drug classes. Surface plasmon resonance (SPR) is widely used for determining antibody affinity, but does not perform well with ex...

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Principais autores:	M. Frank Erasmus, Molly Dovner, Fortunato Ferrara, Sara D’Angelo, André A. Teixeira, Camila Leal-Lopes, Laura Spector, Elizabeth Hopkins, Andrew R. M. Bradbury
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2023-12-01
coleção:	mAbs
Assuntos:	Antibody drug discovery antibody therapeutics surface plasmon resonance kinetic exclusion assay antibody characterization
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/19420862.2023.2291209
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