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Revisiting the Latency of Uridine Diphosphate-Glucuronosyltransferases (UGTs)—How Does the Endoplasmic Reticulum Membrane Influence Their Function?

Uridine diphosphate-glucuronosyltransferases (UGTs) are phase 2 conjugation enzymes mainly located in the endoplasmic reticulum (ER) of the liver and many other tissues, and can be recovered in artificial ER membrane preparations (microsomes). They catalyze glucuronidation reactions in various aglyc...

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Principais autores: Yuejian Liu, Michael W. H. Coughtrie
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2017-08-01
Serier:Pharmaceutics
Fag:
UDP-glucuronosyltransferase
latency
microsomes
glucuronidation
regulation
Online adgang:https://www.mdpi.com/1999-4923/9/3/32
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