Integrative multi-omics analysis identifies a PTM-related immune signature and IRF9 as a driver in ccRCC

BackgroundClear cell renal cell carcinoma (ccRCC) exhibits marked heterogeneity and variable benefit from immune checkpoint inhibitors (ICIs). Post-translational modifications (PTMs) regulate immune signaling and tumor behavior, yet PTM-informed biomarkers for ccRCC remain underexplored.MethodsWe in...

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Hlavní autoři:	Zixiang Li, Xun Li, Simeng Hu, Shan Jiang, Junqi Wang
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-12-01
Edice:	Frontiers in Immunology
Témata:	ccRCC post-translational modifications (PTMs) tumor microenvironment immunotherapy single-cell RNA sequencing IRF9
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1707375/full
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