Insulin growth factor axis and cardio-renal risk in diabetic kidney disease: an analysis from the CREDENCE trial

Abstract Background The insulin-like growth factors (IGF) play a crucial role in regulating cellular proliferation, apoptosis, and key metabolic pathways. The ratio of IGF-1 to IGF binding protein-3 (IGFBP-3) is an important factor in determining IGF-1 bioactivity. We sought to investigate the assoc...

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Autori principali:	Reza Mohebi, Yuxi Liu, Michael K. Hansen, Yshai Yavin, Naveed Sattar, Carol A. Pollock, Javed Butler, Meg Jardine, Serge Masson, Hiddo J. L. Heerspink, James L. Januzzi Jr
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2023-07-01
Serie:	Cardiovascular Diabetology
Soggetti:	IGF-1 Diabetes mellitus Chronic kidney disease Canagliflozin
Accesso online:	https://doi.org/10.1186/s12933-023-01916-2
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