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Tgif1 Counterbalances the Activity of Core Pluripotency Factors in Mouse Embryonic Stem Cells

Core pluripotency factors, such as Oct4, Sox2, and Nanog, play important roles in maintaining embryonic stem cell (ESC) identity by autoregulatory feedforward loops. Nevertheless, the mechanism that provides precise control of the levels of the ESC core factors without indefinite amplification has r...

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Principais autores: Bum-Kyu Lee, Wenwen Shen, Jiwoon Lee, Catherine Rhee, Haewon Chung, Kun-Yong Kim, In-Hyun Park, Jonghwan Kim
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2015-10-01
Series:Cell Reports
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S221112471500964X
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