Markov state models of proton- and pore-dependent activation in a pentameric ligand-gated ion channel

Ligand-gated ion channels conduct currents in response to chemical stimuli, mediating electrochemical signaling in neurons and other excitable cells. For many channels, the details of gating remain unclear, partly due to limited structural data and simulation timescales. Here, we used enhanced sampl...

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Detalhes bibliográficos

Principais autores:	Cathrine Bergh, Stephanie A Heusser, Rebecca Howard, Erik Lindahl
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2021-10-01
coleção:	eLife
Assuntos:	ligand-gated ion channel gating allosteric modulation molecular dynamics electrophysiology markov state model
Acesso em linha:	https://elifesciences.org/articles/68369
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