Ferritin Light Chain Confers Protection Against Sepsis-Induced Inflammation and Organ Injury

Despite the prevalence and recognition of its detrimental impact, clinical complications of sepsis remain a major challenge. Here, we investigated the effects of myeloid ferritin heavy chain (FtH) in regulating the pathogenic sequelae of sepsis. We demonstrate that deletion of myeloid FtH leads to p...

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Detalhes bibliográficos

Principais autores:	Abolfazl Zarjou, Laurence M. Black, Kayla R. McCullough, Travis D. Hull, Stephanie K. Esman, Ravindra Boddu, Sooryanarayana Varambally, Darshan S. Chandrashekar, Wenguang Feng, Paolo Arosio, Maura Poli, Jozsef Balla, Subhashini Bolisetty
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-02-01
coleção:	Frontiers in Immunology
Assuntos:	ferritin inflammatory response sepsis NF-κB cytokine LPS
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.00131/full
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