Blocking peptidyl arginine deiminase 4 confers neuroprotective effect in the post-ischemic brain through both NETosis-dependent and -independent mechanisms

Abstract Peptidylarginine deiminase 4 (PAD4) is an enzyme that modifies proteins by converting positively charged arginine residues to neutral citrulline residues. This process, termed citrullination, has been known to trigger NETosis, a neutrophil cell death pathway involving the release of neutrop...

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Главные авторы:	Song-I Seol, Sang-A Oh, Dashdulam Davaanyam, Ja-Kyeong Lee
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2025-02-01
Серии:	Acta Neuropathologica Communications
Предметы:	PAD4 NETosis Inflammation MCAO Citrullination
Online-ссылка:	https://doi.org/10.1186/s40478-025-01951-y
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