Fragment library screening by X-ray crystallography and binding site analysis on thioredoxin glutathione reductase of Schistosoma mansoni

Abstract Schistosomiasis is caused by parasites of the genus Schistosoma, which infect more than 200 million people. Praziquantel (PZQ) has been the main drug for controlling schistosomiasis for over four decades, but despite that it is ineffective against juvenile worms and size and taste issues wi...

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Үндсэн зохиолчид:	Lauro Ribeiro de Souza Neto, Bogar Omar Montoya, José Brandão-Neto, Anil Verma, Sebastian Bowyer, José Teófilo Moreira-Filho, Rafael Ferreira Dantas, Bruno Junior Neves, Carolina Horta Andrade, Frank von Delft, Raymond J. Owens, Nicholas Furnham, Floriano Paes Silva-Jr
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Nature Portfolio 2024-01-01
Цуврал:	Scientific Reports
Онлайн хандалт:	https://doi.org/10.1038/s41598-024-52018-2
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!