Targeting cardiomyocyte ADAM10 ectodomain shedding promotes survival early after myocardial infarction

Therapeutic interference with the immune response after myocardial infarction holds the potential to close a clinically relevant gap. Here, the authors show that inhibition of a cardiomyocyte-specific ADAM10 / CX3CL1 axis improves post infarction survival and cardiac function by attenuating neutroph...

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Библиографические подробности

Главные авторы:	Erik Klapproth, Anke Witt, Pauline Klose, Johanna Wiedemann, Nikitha Vavilthota, Stephan R. Künzel, Susanne Kämmerer, Mario Günscht, David Sprott, Mathias Lesche, Fabian Rost, Andreas Dahl, Erik Rauch, Lars Kattner, Silvio Weber, Peter Mirtschink, Irakli Kopaliani, Kaomei Guan, Kristina Lorenz, Paul Saftig, Michael Wagner, Ali El-Armouche
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Nature Portfolio 2022-12-01
Серии:	Nature Communications
Online-ссылка:	https://doi.org/10.1038/s41467-022-35331-0
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