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Chronic alcohol intake disrupts cytochrome P450 enzyme activity in alcoholic fatty liver disease: insights into metabolic alterations and therapeutic targets

IntroductionAlcoholic fatty liver disease (AFLD) is a common consequence of chronic alcohol consumption, characterized by lipid accumulation and oxidative stress in the liver. Cytochrome P450 (CYP450) enzymes play essential roles in metabolizing alcohol and other compounds. However, the specific lon...

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Главные авторы: Qian Zhu, Xuefeng Xie, Ling Fang, Cheng Huang, Jun Li
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2025-05-01
Серии:Frontiers in Chemistry
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Online-ссылка:https://www.frontiersin.org/articles/10.3389/fchem.2025.1509785/full
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