Challenges Facing Airway Epithelial Cell-Based Therapy for Cystic Fibrosis

Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene cause the life-limiting hereditary disease, cystic fibrosis (CF). Decreased or absent functional CFTR protein in airway epithelial cells leads to abnormally viscous mucus and impaired mucociliary transport, resulting in...

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Autors principals:	Andrew Berical, Rhianna E. Lee, Scott H. Randell, Finn Hawkins
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2019-02-01
Col·lecció:	Frontiers in Pharmacology
Matèries:	cystic fibrosis cell-based therapy induced pluripotent stem cells human bronchial epithelial cells engraftment
Accés en línia:	https://www.frontiersin.org/article/10.3389/fphar.2019.00074/full
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