From bench to brain: novel thieno-oxazine hybrids as potent pleiotropic anti-Alzheimer’s agents with in vivo/in vitro validation and in silico insights

Due to their various pharmacological effects, several substituted sulphur heterocycles containing thiophene have recently attracted a great deal of attention. A novel 2,3-diaryl-2,3,5,6,7,8-hexahydro-4H-benzo[4,5]thieno[3,2-e][1,3]oxazin-4-one (9–14) was synthesised starting from cyclohexa[b]thiophe...

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Үндсэн зохиолчид:	Eman A. Fayed, Mazin A. A. Najm, Khulood H. Oudah, Maha A. Ebrahim, Nirvana A. Gohar, Karema Abu-Elfotuh, Ehsan Khedre Mohamed, Ahmed M. E. Hamdan, Najla A. Albalawi, Shahad Faisal Alzahrani, Amira M. Hamdan, Reema Almotairi, Shaimaa M. Hafez, Triveena M. Ramsis
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Taylor & Francis Group 2026-12-01
Цуврал:	Journal of Enzyme Inhibition and Medicinal Chemistry
Нөхцлүүд:	Thieno-oxazines Alzheimer’s disease AChE and BChE inhibitors ADMET and docking studies multi-targets and histopathological examinations
Онлайн хандалт:	https://www.tandfonline.com/doi/10.1080/14756366.2025.2598741
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!